Unlocking global potential for Chinese oncology asset

Tags

China to US
Public
Oncology
Newco
US market entry

Overview

A multinational biopharmaceutical developer engaged Treehill Partners to provide strategic expertise.

The developer had advanced an oncology asset to Phase II clinical results. The asset had been developed in combination with a separate development-stage product owned by a third party.

Situation and Challenges

While the asset demonstrated strong potential, development challenges emerged:

  • Geographic Data Limitation
    All clinical data had been generated solely in China.
  • Global Market Access
    To secure investment and ensure entry into the US market, the developer needed to generate US-based clinical data in context of US standard of care.
  • Investor Readiness
    The asset needed a structured investor-focused development narrative to enhance its attractiveness for global capital.

Treehill Solution

Investor Lens Review

Leveraged deep experience in investment and funding to evaluate the asset’s development trajectory from an investor perspective.

Target Product Profile (TPP) Refinement

Redefined the TPP for commercial relevance, aligning it with global investor expectations and US market potential.

Newco Feasibility

Explored the creation of a US-based Newco to orchestrate development, positioning the asset more strategically for US entry.

Redirection of Clinical Development Plan (CDP)

Based on refined insights, reshaped the CDP to optimize value creation trajectory and de-risking profile.

Conclusion and Outcome

With Treehill Partners’ involvement:

  • The oncology asset began attracting significant levels of capital from global investors
  • Development was oriented towards the US market for a set of competitive, relevant commercial positionings in target indications aligned with the asset’s mechanism of action
  • This strategic shift not only enhanced the probability of clinical success but also ensured a more commercially-relevant development outcome upon success

Treehill Partners successfully transformed a regionally-developed oncology asset into a globally investable opportunity with strong prospects for U.S. commercialization.

Investor Lens Review

Leveraged deep experience in investment and funding to evaluate the asset’s development trajectory from an investor perspective.

Target Product Profile (TPP) Refinement

Redefined the TPP for commercial relevance, aligning it with global investor expectations and US market potential.

Target Product Profile (TPP) Refinement

Redefined the TPP for commercial relevance, aligning it with global investor expectations and US market potential.

Target Product Profile (TPP) Refinement

Redefined the TPP for commercial relevance, aligning it with global investor expectations and US market potential.

Treehill Partners applied its multidisciplinary expertise to realign the development strategy:

Investor Lens Review

Leveraged deep experience in investment and funding to evaluate the asset’s development trajectory from an investor perspective.

Target Product Profile (TPP) Refinement

Redefined the TPP for commercial relevance, aligning it with global investor expectations and US market potential.

Newco Feasibility

Explored the creation of a US-based Newco to orchestrate development, positioning the asset more strategically for US entry.

Redirection of Clinical Development Plan (CDP)

Based on refined insights, reshaped the CDP to optimize value creation trajectory and de-risking profile.